Obesity has become a major epidemic especially in developed countries, and is tightly associated with multiple co-morbidities, including insulin resistance, type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. Diet Induced Obesity (DIO) model is a non-genetic model of obesity where the mice are fed with high fat diet for 6-12 weeks to induce obesity, fatty liver, hyperlipidemia, hyperinsulinemia, and insulin resistance. This model is suitable for investigating the effect of anti-obesity compounds and associated conditions. DIO mice are also widely used to analyze the efficacy of compounds using glucose tolerance test (GTT), insulin tolerance test (ITT) and hyperinsulinemic-euglycemic clamp studies.

If your projects require studies in DIO mice or you are interested in further details, please contact Triangulum scientists. We offer preclinical efficacy, proof-of-concept, and mechanism of action studies with your drug candidates. We work with our clients in providing scientific guidance, customized study design, end-point analysis, histopathology services, and will assist you with professional interpretation of the data. Please contact us with your specific needs.

Relevant publications by our scientists: 1. Watts LM, Manchem VP, Leedom TA, Rivard AL, McKay RA, Bao D, Neroladakis T, Monia BP, Bodenmiller DM, Cao JX, Zhang HY, Cox AL, Jacobs SJ, Michael MD, Sloop KW, Bhanot S. Diabetes. 2005, 54(6):1846-1853. PMID: 15919808

2. Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M, Watts L, Booten SL, Graham M, McKay R, Subramaniam A, Propp S, Lollo BA, Freier S, Bennett CF, Bhanot S, Monia BP. Cell Metab. 2006 Feb;3(2):87-98. PMID: 16459310

3. Pandey SK, Yu XX, Watts LM, Michael MD, Sloop KW, Rivard AR, Leedom TA, Manchem VP, Samadzadeh L, McKay RA, Monia BP, Bhanot S. J Biol Chem. 2007 May 11;282(19):14291-14299. PMID: 17353188

4. Yu XX, Pandey SK, Booten SL, Murray SF, Monia BP, Bhanot S. Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E530-9. doi: 10.1152/ajpendo.00350.2007. PMID: 18198353

5. Yu XX, Watts LM, Manchem VP, Chakravarty K, Monia BP, McCaleb ML, Bhanot S. PLoS One. 2013 29;8(7):e66923. doi: 10.1371/journal.pone.0066923. PMID: 23922646