Chronic Kidney Disease (CKD) is a progressive and long-term condition in which kidney function is impaired. The high prevalence of CKD represents a significant hazard to human health. Diabetes and hypertension are the major causes of CKD. It is characterized by renal cell loss and their replacement by extracellular matrix (ECM)resulting in glomerulosclerosis and tubulointerstitial fibrosis.There are currently no FDA-approved drugs for CKD and renal fibrosis, and recent advances have identified the cellular mechanisms responsible for fibrogenesis. Some investigative antifibrotic drugs show a significant efficacy in slowing down and even reversing the fibrosis in animal models.
Triangulum Biopharma offers preclinical rodent pharmacology services in Adenine Induced CKD with severe anemia and renal Interstitial Fibrosis Mouse Model, and Unilateral Ureteral Obstruction (UUO) Mouse Model